Accuracy of kidney dosimetry performed using simplified time activity curve modelling methods: a < sup > 177 < /sup > Lu-DOTATATE patient study.

Accuracy of kidney dosimetry performed using simplified time activity curve modelling methods: a ¹⁷⁷Lu-DOTATATE patient study.
Phys Med Biol. 2019 Jul 09;:
Authors: Zhao W, Esquinas PL, Frezza A, Hou X, Beauregard JM, Celler A
Abstract
&amp;lt;sup&amp;gt;177&amp;lt;/sup&amp;gt;Lu-DOTATATE therapy has been shown to produce encouraging results in treatment of neuroendocrine tumours (NETs). Unfortunately, since dosimetry for radionuclide therapy is considered to be challenging, typically similar amount of radiopharmaceutical is administered to every patient. There is growing evidence that the efficacy of this therapy can be significantly improved by employing personalized protocols, based on the organ-at-risk dosimetry. The aim of this study is to propose a practical and accurate dosimetry protocol based on the simplified acquisition schedules. &amp;#13; &amp;#13; Data from fifty-three therapy cycles in thirty-nine NET patients were analyzed. Three SPECT/CT scans, acquired at 4h (D0), 23h (D1) and 70h (D3) after injection, were performed. The kidney volume was determined using CT and the activity was determined from quantitative SPECT using an iterative thresholding method. For each dataset, four methods were used to model the time-activity-curves (TAC): M1 - two trapezoid segments (0 to D0 and D0 to D1), followed by monoexponential fit to D1+D3 data; M2 - monoexponential fit to D0+D1+D3 da...

Source: Physics in Medicine and Biology - July 8, 2019 Category: Physics Authors: Zhao W, Esquinas PL, Frezza A, Hou X, Beauregard JM, Celler A Tags: Phys Med Biol Source Type: research