Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: An in vitro and in vivo study in aortic stenosis

Conclusions: sST2 affected mitochondrial fusion in human cardiac fibroblasts, increasing oxidative stress production and inflammatory markers secretion. The blockade of NFkB or mitochondrial reactive oxygen species restored MFN-1 expression, improving oxidative stress status and reducing inflammatory markers secretion. In human AS, cardiac sST2 levels associated with oxidative stress and inflammation. The present study reveals a new pathogenic pathway by which sST2 promotes oxidative stress and inflammation contributing to cardiac damage.

Source: Clinical Science - July 7, 2019 Category: Biomedical Science Authors: Matilla, L., Ibarrola, J., Arrieta, V., Garcia-Pena, A., Martinez-Martinez, E., Sadaba, R., Alvarez, V., Navarro, A., Fernandez-Celis, A., Gainza, A., Santamaria, E., Fernandez-Irigoyen, J., Bayes-Genis, A., Rossignol, P., Lopez-Andres, N. Tags: PublishAheadOfPrint Source Type: research