Effect of exosomes from adipose-derived stem cells on the apoptosis of Schwann cells in peripheral nerve injury.

CONCLUSION: Our results present a novel exosome-mediated mechanism for ADSC-SC cross talk that reduces the apoptosis and promotes the proliferation of SCs and may have therapeutic potential in the future. PMID: 31278850 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research

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Introduction: Options for therapy of severe burns are limited and generally include local wound care, debridement, grafting, and long-term care. Mesenchymal stem cells (MSCs) have been used in applications directed at the repair and regeneration of damaged tissue. There is little known regarding the clinical application of allogenic MSCs in the treatment of second degree burn injury. This pilot study establishes the safety of MSC therapy for burn wounds in two dose escalations, in addition to providing both observational and objective data that this treatment protocol improves the healing of these injuries.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Thermal injury leads to loss of the regenerative capacity of the skin and scarring becomes a significant risk, due to the inability to emulate normal skin architecture and adnexal structures. Mesenchymal stem cells (MSC) have been used in a variety of clinical applications to repair and regenerate damaged tissue. MSC ’s can stimulate cellular processes such as fibroblast proliferation, migration, and endothelial angiogenesis, as well as modulate the host’s immune response to favor more optimal wound healing.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 20 August 2019Source: Stem Cell ResearchAuthor(s): Flavia S. Donaires, Raquel M. Alves-Paiva, Fernanda Gutierrez-Rodrigues, Fernanda Borges da Silva, Maria Florencia Tellechea, Lilian Figueiredo Moreira, Barbara A. Santana, Fabiola Traina, Cynthia E. Dunbar, Thomas Winkler, Rodrigo T. CaladoAbstractTelomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short telomeres. X-linked dyskeratosis congenita (DC), the prototypical telomere disease, manifested with ectodermal dysplasia, cance...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Saidi RF, Moghadasali R, Shekarchian S Abstract There has been ample of preclinical and animal studies whichshowed efficacy and safety of using mesenchymal stem cells (MSCs)after transplantation for tissue repair, immunosuppression ortolerance induction. However, there has been a significant progressrecently using MSCs in small clinical trials after transplantation. Recent results using MSCs after transplantation seem to befeasible and safe. However, there are some limitations to show theeffectiveness of these cells including source, dose, timing and routeof infusions. Currently, live donor kidney transpla...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Libin Pang, Yifan Shen, Haoran Hu, Xiangqiong Zeng, Wenhai Huang, Hong Gao, Hui Wang, Deping WangAbstractThe composite scaffolds of bioactive glasses and polymers are often used in bone regeneration which could improve the stiffness, compressive strength and bioactivity of polymers while maintaining the osteoconductivity and osteoinductivity of bioactive glasses. But due to complicated situations and limitations of compositing process, the prepared composite materials have low uniformity and obvious phase separation, leading t...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Background: Stem cell therapy of acute myocardial infarction is proving to be a promising approach to repair the injured myocardia. However, the time window for stem cell transplantation is important and yet difficult to determine since it produces much different therapeutic effect at different times after myocardial infarction. Stromal cell-derived factor-1 (SDF-1) plays a pivotal role in the mobilization, homing, proliferation and differentiation of transplanted stem cells. Here, by using of ultrasound molecular imaging via targeted microbubbles, we determined the dynamic expression of SDF-1 in a swine model of acute myo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Skeletal muscle is composed of a large and heterogenous assortment of cell populations that interact with each other to maintain muscle homeostasis and orchestrate regeneration. Although Satellite Cells (SCs) - which are muscle stem cells - are the protagonists of functional muscle repair following damage, several other cells such as inflammatory, vascular and mesenchymal cells coordinate muscle regeneration in a finely tuned process. Fibro-Adipogenic Progenitors (FAPs) are a muscle interstitial mesenchymal cell population, which supports SCs differentiation during tissue regeneration. During the first days following mus...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Yuan Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein. p21 is transcriptionally controlled by p53 and p53-independent pathways. Its expression is increased in response to various intra- and extracellular stimuli to arrest the cell cycle ensuring genomic stability. Apart from its roles in cell cycle regulation including mitosis, p21 is involved in differentiation, cell migration, cytoskeletal dynamics, apoptosis, transcription, DNA repair, reprogramming of induced pluripotent stem ce...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Shichao Bi, Pengjun Wang, Shihao Hu, Shaoke Li, Jianhui Pang, Zhongzheng Zhou, Guohui Sun, Liang Huang, Xiaojie Cheng, Shichao Xing, Xiguang ChenAbstractWeak mechanical properties, lack biocompatibility and relatively bioinert are formidable obstruct in application of bone repair materials. Multifunctional composite materials have been considered as a viable solution to this problem. Here, a new double network (DN) hydrogel was constructed by physical cross-linking of medical grade poly (vinyl alcohol) (PVA) and chitosan in KOH/urea disso...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
The brain's V ‐SVZ is a site of type B NSC‐mediated neurogenesis and unfortunately for very aggressive GBM. Treatment for GBM consists of resection, concurrent temozolomide (TMZ) and X‐irradiation (XRT) followed by adjuvant TMZ. We show that concurrent TMZ/XRT followed by adjuvant TMZ induces apoptosis in t ype A neuroblasts. In contrast, quiescent NSCs, which express high levels Bcl2 and Mcl1, survive and repopulate type A neuroblasts. AbstractThe ventricular ‐subventricular zone (V‐SVZ) of the mammalian brain is a site of adult neurogenesis. Within the V‐SVZ reside type B neural stem cells (NSCs) and type A n...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Translational and Clinical Research Source Type: research
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