Calcosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis. This article is protected by copyright. All rights reserved.
PMID: 31276230 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: El-Kott AF, Al-Kahtani MA, Shati AA Tags: Clin Exp Pharmacol Physiol Source Type: research
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