Mechanisms underlying the EEG biomarker in Dup15q syndrome

ConclusionsOur results suggest a critical role for GABAergic transmission in the Dup15q syndrome beta EEG phenotype, which cannot be explained byUBE3A dysfunction alone. If this mechanism is confirmed, the phenotype may be used as a marker of GABAergic pathology in clinical trials for Dup15q syndrome.

Source: Molecular Autism - July 2, 2019 Category: Molecular Biology Source Type: research