Inhibition of amyloid ‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

This study investigates ET’s potential to counteract Aβ‐toxicity in transgenicCaenorhabditis  elegans overexpressing a human A β peptide. The accumulation of Aβ in this model leads to paralysis and premature death. We show that ET dose‐dependently reduces Aβ‐oligomerization and extends the lifespan and healthspan of the nematodes.

Source: FEBS Letters - June 29, 2019 Category: Biochemistry Authors: Irwin K. Cheah, Li ‐Theng Ng, Li‐Fang Ng, Vanessa Y. Lam, Jan Gruber, Cheryl Y.W. Huang, Fang‐Qin Goh, Keith H.C. Lim, Barry Halliwell Tags: Research Letter Source Type: research