Cancers, Vol. 11, Pages 919: The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro

In conclusion, CDV inhibits cell growth in HPV-positive and -negative HNSCC cell lines and was more profound in the HPV-positive cell lines. CDV treated cells show accumulation of DNA DSBs and DNA damage response activation, but apoptosis does not seem to occur. Rather our data indicate the occurrence of mitotic catastrophe.

Source: Cancers - June 29, 2019 Category: Cancer & Oncology Authors: Femke Verhees Dion Legemaate Imke Demers Robin Jacobs Wisse Evert Haakma Mat Rousch Bernd Kremer Ernst Jan Speel Tags: Article Source Type: research