Blast-mediated traumatic brain injury exacerbates retinal damage and amyloidosis in the APPswePSENd19e mouse model of Alzheimer's disease - Harper MM, Hedberg-Buenz A, Herlein J, Abrahamson EE, Anderson MG, Kuehn MH, Kardon RH, Poolman P, Ikonomovic MD.

PURPOSE: Traumatic brain injury (TBI) is a risk factor for developing chronic neurodegenerative conditions including Alzheimer's disease (AD). The purpose of this study was to examine chronic effects of blast TBI on retinal ganglion cells (RGC), optic nerv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Related Links:

Publication date: 7 December 2019Source: New Scientist, Volume 244, Issue 3259Author(s): Adam VaughanAs fires continue to burn in Australia, an analysis predicts that linked global carbon emissions have risen further, reports Adam Vaughan
Source: New Scientist - Category: Science Source Type: research
In conclusion, this systematic review and meta-analysis found that compared to non-nicotine/smoking, non-alcohol, non-substance use burn patients, patients using nicotine/smoking, alcohol, and/or substances were associated with more burn related operations, higher rates of graft loss/failure, longer hospital LOS (length of stay), higher rates of intubation, longer ICU (intensive care unit) LOS, increased mortality, and increased wound/local skin infections. Patients using nicotine/smoking were associated with higher rates of intubation and wound/local skin infections. Patients consuming alcohol were associated with more da...
Source: Burns - Category: Dermatology Source Type: research
CONCLUSIONS: This study did not support an association between statin use and diagnostic conversion but suggested a possible association between statin use and cognitive change in EMCI. Additional randomized clinical trials of statins may be warranted in the prodromal EMCI stage of AD. PMID: 31806426 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Publication date: 1 January 2020Source: Neuroscience, Volume 424Author(s): Eva-Lotta von Rüden, Christina Zellinger, Julia Gedon, Andreas Walker, Vera Bierling, Cornelia A. Deeg, Stefanie M. Hauck, Heidrun PotschkaAbstractClinical evidence and pathological studies suggest a bidirectional link between temporal lobe epilepsy and Alzheimer’s disease (AD). Data analysis from omic studies offers an excellent opportunity to identify the overlap in molecular alterations between the two pathologies.We have subjected proteomic data sets from a rat model of epileptogenesis to a bioinformatics analysis focused on proteins ...
Source: Neuroscience - Category: Neuroscience Source Type: research
EARLY PREDICTION OF ALZHEIMER'S DISEASE DEMENTIA BASED ON BASELINE HIPPOCAMPAL MRI AND 1-YEAR FOLLOW-UP COGNITIVE MEASURES USING DEEP RECURRENT NEURAL NETWORKS. Proc IEEE Int Symp Biomed Imaging. 2019 Apr;2019:368-371 Authors: Li H, Fan Y, Alzheimer’s Disease Neuroimaging Initiative Abstract Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when and which mild cognitive impairment (MCI) individuals will convert to...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
This study aimed to investigate the effect of high-mobility group box 1 (HMGB1) protein and its mechanism in diabetic retinopathy (DR) were investigated.Main methodsHuman retinal endothelial cells (HREC) were uesd for chip-seq. Sprague Dawley (SD) rats were randomly divided into control group, HMGB1 group, diabetes mellitus (DM) combined with HMGB1 siRNA group, and DM group. Next, eyeballs were removed and retinas were detached for western blot. The DM model of cell was built by increasing the glucose concentration in cell culture medium. The regulation of HMGB1 was achieved by short hairpin (sh)-HMGB1 transfection, then, ...
Source: Life Sciences - Category: Biology Source Type: research
An approach was proposed to predict skin burns during heat exposure based on Computational Fluid Dynamics and Python language. Both of uniform and heterogeneous skin thickness distributions of the whole body were considered and significant differences were...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
This article argues that while the consequences of CWs on indi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Colorful balls of light and glittering sparks of sparkle against the dark night sky, exuberant people and the generational anticipation of a new year: Over the past few years, more than 130 million euros have been spent on private fireworks in Germany....
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
OBJECTIVES: Exploration of experience of harms due to another person's drinking within a demographic particularly vulnerable to these consequences. Importance of study: Largest sampling of young Australian risky drinkers, who are underrepresented in genera...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
More News: Alzheimer's | Amyloidosis | Brain | Burns | Ganglions | International Medicine & Public Health | Neurology | Study | Vitamin A