Design, synthesis, and evaluation of isoquinoline ureas as TRPV1 antagonists.

CONCLUSION: The para-substituted analogues were found to be more potent than the ortho- and meta- analogues in biological assay. This observation was further supported by molecular modeling studies using CoMFA. PMID: 31241438 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research