Design, synthesis, and evaluation of isoquinoline ureas as TRPV1 antagonists.
CONCLUSION: The para-substituted analogues were found to be more potent than the ortho- and meta- analogues in biological assay. This observation was further supported by molecular modeling studies using CoMFA.
PMID: 31241438 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Gujarati NA, Undem BJ, Korlipara VL Tags: Med Chem Source Type: research
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