Assessing Patient Preferences for Treatment Decisions for New Direct Acting Antiviral (DAA) Therapies for Chronic Hepatitis C Virus Infections

This study elicited the preferences of CHC patients for treatment attributes of new DAAs.MethodsAn online discrete choice experiment survey was designed to collect data from adult CHC patients in the USA, UK, France, Germany, Spain, and Italy. Patients were asked to choose from alternative hypothetical DAA options, defined by differing levels of nine attributes [i.e., treatment duration, tablet count and packaging, cure rate, required office visits when on treatment, modifications to statins or to proton pump inhibitors (PPIs), and risks of diarrhea, headache and nausea]. Logistic regression was used to assess preference for the treatment options.ResultsA total of 328 patients with CHC completed the survey (USA,n = 227; European countries,n = 101), with a mean age of 47.7 years (SD = 14.4) and an average 11.2 years since CHC diagnosis; 51% of patients were female. More than half (60%) of the patients had treatment for CHC. Patients significantly preferred a DAA regimen with higher cure rate, shorter treatment duration, lower risks of diarrhea, headache, and nausea (allp 
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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ConclusionsThe results suggested that KXS exerted antidepressant effects by regulating the signaling pathways involved in lipid metabolism disorders. The lipid metabolites might be potential biomarkers of depression and possible targets for KXS-based treatment of depression.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Daniel Ejim Uti, Item Justin Atangwho, Eyong Ubana Eyong, Grace Ufedo Umoru, Godwin Eneji Egbung, Victor Udo Nna, Precious A. UdeozorAbstractAimsAfrican walnuts were previously shown to modulate hepatic lipid bio-accumulation in obesity. Herein, we investigated the impact of the nuts on fat accumulation in adipose and ectopic regions, and associated oxidatiive stress status in obese rats.Materials and methodsWhole ethanol extract (WE) of the nuts, and its liquid-liquid fractions-ethyl acetate (ET) and residue (RES) were separately ad...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Cosentino E, Palmer K, Della Pietà C, Mitolo M, Meneghello F, Levedianos G, Iaia V, Venneri A Abstract AIMS: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between gait and gray matter volumes. MATERIALS AND METHODS: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). Participants underwent comprehensive neuropsychological assessment. Gait speed, cadence,...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
The objective of this work was to assess the roles and missions of existing registries and to reflect on their positioning in this new environment. The French model of registry is sometimes questioned because of the complexity of its circuits, requiring a significant amount of human resources. However, the data that constitute them, validated by cross-checking information from several sources, are of very high quality, and make it possible to validate the data in the new databases (National Health Data System (NSDS) or Hospital Data Warehouses). Registries and new databases are in fact complementary, and far from jeopardiz...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Publication date: Available online 25 January 2020Source: Food ChemistryAuthor(s): R. Rodríguez-Vázquez, A. Mato, M. López-Pedrouso, D. Franco, M.A. Sentandreu, C. ZapataAbstractEstimates of quantitative proteomic distance between populations have not been reported to date. Here, quantitative proteomic distances between three Spanish bovine breeds (Asturiana de los Valles, AV; Retinta, RE; and Rubia Gallega, RG) were estimated from two-dimensional electrophoresis profiles of meat samples of longissimus thoracis muscle at 2 h post-mortem. Statistically significant distances were detected between AV/RG a...
Source: Food Chemistry - Category: Food Science Source Type: research
CONCLUSION: There is higher AROPE prevalence in Valencia. Social class and family type were shared factors, but a differential pattern is observed in other social determinants. It is essential to implement social policies to reduce this axis of inequalities in health, especially in childhood. PMID: 31980149 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Authors: Garg S, Khechoyan D, Kim EB, French B Abstract Wound complications after pediatric spinal deformity surgery are a relatively common and challenging complication that results in emotional, physical, and monetary costs to the patients, families, and healthcare providers. The role of wound closure techniques for the prevention of wound complications is being increasingly explored. Interdisciplinary care by spinal surgeons and plastic surgeons has been recently found to decrease wound complication rates in patients with nonidiopathic scoliosis. PMID: 31977607 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Officials announce new measures to contain disease, including wildlife trade ban and bus suspensions, as confirmed death toll reaches 56Coronavirus ’s ability to spread getting stronger, China suggestsScientists race to discover how Wuhan victims were infectedWhere has coronavirus spread?1.21pmGMT12.58pmGMTWorld Animal Protection has welcomed China ’s decision to impose a wildlife trade ban, effective from today.Kate Nustedt, the organisation ’s global wildlife director, said:We commend China ’s decision to impose a nationwide ban on wildlife trade in response to the deadly coronavirus outbreak. Thi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak China Health Asia Pacific Society Science World news Americas Europe Australia news France Hong Kong Infectious diseases Source Type: news
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Source: Journal of Psychoactive Drugs - Category: Psychiatry & Psychology Authors: Source Type: research
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Source: Developmental Neuropsychology - Category: Neurology Authors: Source Type: research
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