The Impact of Diet on the Persistence of Early Vascular Remodeling and Stiffening Induced by Intrauterine Growth Restriction and a Maternal High-fat Diet.

The Impact of Diet on the Persistence of Early Vascular Remodeling and Stiffening Induced by Intrauterine Growth Restriction and a Maternal High-fat Diet. Am J Physiol Heart Circ Physiol. 2019 Jun 21;: Authors: Miller TA, Dodson RB, Mankouski A, Powers KN, Yang Y, Yu B, Zinkhan EK Abstract Intrauterine growth restriction (IUGR) and maternal high-fat diet (HFD) independently predispose offspring to hypertension. In a rat model, IUGR more so than maternal HFD increases arterial stiffness with vascular remodeling as early as post-natal day (PND) 21. The trajectory of such early vascular changes remains unknown. We hypothesized that IUGR would increase blood pressure (BP), arterial stiffness, and markers of ongoing detrimental vascular remodeling in adult rats exposed to a maternal HFD regardless of weaning diet. Adult female rats were fed either a regular diet (RD) or an HFD prior to mating through lactation. IUGR was induced by uterine artery ligation. Offspring were weaned to either a RD or HFD through PND 60. For both control (C) and IUGR (I) rats, this design resulted in 3 diet groups: offspring from RD dams weaned to a RD (CRR and IRR) and offspring from HFD dams weaned to a RD (CHR and IHR) or to an HFD (CHH and IHH). In both males and females, only IHH increased systolic BP, but IUGR and HFD both alone and in combination increased arterial stiffness. Aortas contained fewer but thicker elastin bands in IHH and IHR rats. IHH increa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research