Diclofenac-induced thrombotic thrombocytopenic purpura with concomitant complement dysregulation: a case report and review of the literature

ConclusionThrombotic thrombocytopenic purpura is a rare condition that can be acquired. Our case is rare because it represents the first report of diclofenac potassium-induced thrombotic thrombocytopenic purpura with subjacent complement activation and dysregulation. Early recognition and aggressive management led to a favorable outcome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research

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Unfortunately I manage and fill about 30 IT pumps in my current gig. I feel like I have a good system down to make extra sure I am always through the port and in the pump before I ever inject any medicine. I accessed a patient's Medtronic pump earlier today, took out the old medicine without any problems. Needle stays firmly in pump, never moves. I go to inject the new medicine (40ml pump so difficult to inject as per usual tactile feedback) and after about 3-4 cc's the patient says that she... Weird Pump Reaction
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
This study aimed to determine the frequency and pattern of different granulomatous skin lesions in the Dermatopathology Department of Hospital de Santa Maria (Lisboa, Portugal). A retrospective study of all skin biopsies with granulomatous lesions received during a period of 10 years (2008–2017) was performed. Clinical and histopathological characteristics of the selected cases were analyzed, and the lesions were categorized according to histological type of granuloma and etiology. Foreign-body granulomas secondary to ruptured cyst, folliculitis, or suture material were excluded. From a total of 48,253 cutaneous biop...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: CME Article Source Type: research
Abstract: Significant communication occurs between pathologists and clinicians through the dermatopathology report. Our objective was to describe clinician preference about reporting of the margin status of skin biopsies of nonmelanoma skin cancers. An anonymous survey was sent to 243 medical providers who submitted specimens to a single institution university medical center; 50 complete responses from attending-level providers and advance practice providers were received. The majority (96%) of those surveyed indicated margins should be reported on skin biopsies of neoplasms, particularly nonmelanoma skin cancers (basal ...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
Abstract: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT), is a rare subtype of non-Hodgkin lymphoma associated with Epstein–Barr virus. This type of lymphoma is rare in Western countries but is more frequent in East Asia and Latin America. ENKTL-NT mostly occurs in the nose and paranasal area, including the upper aerodigestive tract. The skin is the second-most commonly involved organ. ENKTL-ET is characterized by an angiocentric, angiodestructive pattern of growth with ulceration and necrosis evident on histopathological examination. We provide the first description of ENKTL-NT presenting with in...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research
Conclusions: Sufficient deltoid tensioning is vital to the stability of a reverse prosthesis as well as patient range of motion and outcomes; however, increased deltoid lengthening during reverse total shoulder arthroplasty increases the risk of postoperative tension-related complications. These data suggest that lengthening more than 26 mm is a risk factor for deltoid-related complications after reverse total shoulder arthroplasty. Level of Evidence: Level III.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
This study aimed to elucidate any connection between central sensitization and ongoing pain after knee replacement surgery and other associated factors. Methods: The population was composed of 182 patients who had undergone TKR, and in follow-up visits from 1 mo to 2 yr after the operation, they were evaluated using the Pressure Pain Threshold (PPTs), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Central Sensitization Inventory (CSI), the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), the Beck Depression Inventory (BDI), and the painDETECT test. Results: Th...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
Conclusions: For one-level ACDF, the anchored cage with screws has some advantage compared to the stand-alone PEEK cage in avoiding dysphagia and restoring disc space height and cervical lordosis. We suggest the anchored spacer may be a good substitute for the stand-alone cage in one-level ACDF. Level of Evidence: Level II
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
We report a case of a 48-year-old Caucasian woman who was treated at the University General Hospital of Alicante. She consulted because of progressive abdominal pain over the last seven months, with the initial diagnosis of renal-ureteral colic. Ultrasound and computed tomography of the abdomen and pelvis revealed a 25x15 cm, well-defined cystic lesion with papillary projections, centrally located in the abdomen. The radiology report suggested a primary ovarian tumor versus peritoneal implant as the first option. The patient underwent an exploratory laparotomy showing a large cystic mass located in the urinary bladder peri...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but they also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. To this end, From the AJN Archives highlights articles selected to fit today's topics and times. In this month's article, from the May 1925 issue, nurse Ellen G...
Source: AJN - Category: Nursing Tags: From the AJN Archives: PDF Only Source Type: research
Two drugs, voxelotor (Oxbryta) and crizanlizumab-tmca (Adakveo), have been approved to treat sickle cell disease.The most common adverse effects of voxelotor are diarrhea, headache, abdominal pain, nausea, fatigue, rash, and fever. Hypersensitivity reactions are also possible.The most common adverse effects of crizanlizumab-tmca are back pain, nausea, fever, and arthralgia. Serious adverse effects include infusion-related reactions and interference with automated platelet counts.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
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