Regeneration of large bone defects using mesoporous silica coated magnetic nanoparticles during distraction osteogenesis

This study demonstrates the notable potential of M-MSNs in promoting bone regeneration during DO by enhancing the osteogenic differentiation of MSCs, paving the way for clinical translation of M-MSNs in DO to repair large bone defects.Graphical AbstractTranslational potential of mesoporous silica coated iron oxide nanoparticles (M-MSNs) in regenerating long bone defects during distraction osteogenesis. Local injection of M-MSNs to the distraction gap promotes new bone formation and consolidation through enhancing the osteogenic differentiation of mesenchymal stem cells via the Wnt/β-catenin signaling pathway.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research