Current mechanistic insights into the role of infection in systemic lupus erythematosus
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Qingjun Pan, Zejian Liu, Shuzhen Liao, Lin Ye, Xing Lu, Xiaoqun Chen, Zhihang Li, Xinxin Li, Yong-Zhi Xu, Huafeng LiuAbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotropic virus type 1, human immunodeficiency virus type 1, and endogenous retroviruses) in the pathogenesis of SLE. More importantly, we explore the known mechanisms underlying the involvement of infectious agents in the pathogenesis of SLE, including molecular mimicry, epitope spreading, superantigen production, bystander activation, persistent viral infection, altered apoptosis, clearance deficiency, and epigenetic alterations (e.g., DNA methylation and microRNAs). However, some infectious agents (e.g., malaria parasites, hepatitis B virus, Toxoplasma gondii, and Helicobacter pylori) may exert protective effects on SLE. Therefore, the relationship between infection and SLE is multifaceted and multidirectional, including causative and/or protective associations, which warrant further investigation in the future.Graphical abstract
We report a rare case of HLH associated with acute hepatitis E virus infection. PMID: 31325278 [PubMed - in process]
Conclusion: Most common etiology of PRS is ANCA positive vasculitis in India. With high degree of suspicion for DAH in patients presenting with haemoptysis, breathlessness and alveolar opacities in chest x-ray and carefully investigating by simple urine examination for evidence of GN, timely diagnosis of PRS can be made. With timely appropriate treatment survival is 68%. Patients with PRS due to leptospirosis or dengue have features suggestive of underlying disease (like icterus with raised bilirubin but
Authors: Mirgh SP, Mishra VA, Sorabjee JS PMID: 31324102 [PubMed - in process]
Authors: Sarkar R, Paul R, Thakur I, Chatterjee S, Singh S Abstract Scleroderma is a connective tissue disease which may present with renal crisis. But sometimes, acute renal failure in scleroderma may be due to a second pathology. We here present a case of a 35 year old woman with systemic sclerosis, who presented with acute renal failure. She was started treatment as a case of scleroderma renal crisis. But her condition continued to deteriorate and she also developed some cutaneous vasculitic lesions. Her urine also had active sediments. Finally, serology and kidney biopsy established the renal lesion as stage IV...
Authors: Kumar SSS, Palaniandavan S, Bhargavi MV, Gambeer AS, Nithyalakshmi G Abstract Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and it often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. A 30-year-old woman presented with complaints of headache for 1 year on and off. Physical examination revealed nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultraso...
Conclusions: As the pattern of glomerular disease varies from one region to another, the pattern of glomerular disease in the north eastern India also varies from the other regions of India. Nephrotic syndrome remains the most common indication of renal biopsy in this region similar to the other parts of India. Unlike other studies from outside North Eastern India, this study show that females are more commonly involved with majority of them having secondary GD and this is due to LN which was diagnosed as the most common GD in the present study. PMID: 31324082 [PubMed - in process]
CONCLUSION: The SFN treatment showed anti-inflammatory and anti-oxidative effects in the EAE mice. Conclusively, this study suggests that SFN has neuroprotective effects via anti-inflammatory processing, so it could be a new therapeutic or nutritional supplement for MS. PMID: 31327180 [PubMed - in process]
This single-site study aimed to identify risk factors for short-term mortality in patients hospitalized with severe alcoholic hepatitis.Southern Medical Journal
Roche announced today the Global Access Program is expanding beyond HIV, to include Mycobacterium tuberculosis (MTB), Hepatitis B and C (HBV and HCV), and Human Papillomavirus (HPV) for low and middle income country programs where the disease burden is the highest.
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotropic virus type 1, human immunodeficiency virus type 1, and endogenous retroviruses) in the pathogenesis of SLE. More importantly, we explore the known mechanisms underlying the involvement of infectious...