Phospholipase C (PLC) ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line.

CONCLUSIONS The present results suggest that targeting of PLCε/BMP-6/SMAD signaling may increase the sensitivity of CRPC to AR antagonists and inhibit tumor progression. PMID: 31201297 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Authors: van den Wyngaert T, Tombal B Abstract Radium-223 is a life prolonging treatment in symptomatic men with metastatic castrate resistant prostate cancer (mCRPC) and bone metastases, but no visceral disease, regardless of prior treatment with docetaxel. Together with four other drugs (i.e. abiraterone, cabazitaxel, docetaxel, enzalutamide), it has been available for clinical use since 2013 and has been shown to also provide benefits in quality-of-life and societal benefits. However, in 2018 the European Medicines Agency (EMA) ruled to restrict the use of radium-223 to a more advanced disease setting after at l...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Conclusions: Our results demonstrate that miR-216a-5p might serve as a tumor suppressor in ESCC cells through negatively regulating TCTN1 expression, indicating the possibility that miR-216a-5p and TCTN1 might be attractive targets for ESCC therapeutic intervention. PMID: 31297133 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Cell Mol Biol Lett Source Type: research
In this study, We found a lncRNA SNHG7 was overexpressed in PCa cell lines and tissues. LncRNA SNHG7 promotes prostate cancer migration and invasion by modulating EMT. Further study indicated that lncRNA SNHG7 acts as a sponge for miRNA-324-3p and positively regulates WNT2B by a sponge effect. Moreover, We confirmed that WNT2B, an important protein in the Wnt signal pathway, promotes the malignant phenotype of PCa cells and mediated the biological effects exerted by lncRNA SNHG7. Overall, our study suggested that lncRNA SNHG7 could promote PCa EMT via miR-324-3p and WNT2B in vitro. The lncRNA SNHG7/miR-324-3p /WNT2B axis r...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In the eighth edition AJCC staging, all organ-confined disease is assigned pathologic stage T2, without subclassification. We investigated whether total tumor volume (TTV) and/or maximum tumor diameter (MTD) of the index lesion are useful in improving prediction of biochemical recurrence (BCR) in pT2 patients. We identified 1657 patients with digital tumor maps and quantification of TTV/MTD who had pT2 disease on radical prostatectomy (RP). Multivariable Cox regression models were used to assess whether TTV and/or MTD are independent predictors of BCR when adjusting for a base model incorporating age, preoperative prostate...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Authors: Katsuse K, Shiozawa M, Bae Y, Hashida H PMID: 31292401 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Konishi Y, Terada T, Araki Y, Kawaguchi O Abstract Flutamide, a chemotherapeutic agent for prostate cancer, is known to enhance warfarin anticoagulation. However, not much is known about its pharmaceutical interaction. We herein report the case of a patient with an implanted pacemaker for atrial fibrillation with bradycardia who was on warfarin. This patient presented with deterioration of hematuria, gingival, ear, and subcutaneous bleeding. The prothrombin time-international normalized ratio (PT-INR) was extremely elevated after starting flutamide to treat progression of prostate cancer. Fatal bleeding co...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ENLARGED prostate, or prostatic enlargement, isn ’t considered harmful but can affect how you pee. There are three symptoms linked to the condition, but it’s also important to note when these symptoms could be signs of prostate cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Maria Grazia Daidone Enzalutamide and abiraterone have been shown to improve progression-free survival (PFS) and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients. Moreover, some patients may not benefit from the inhibition of androgen receptor (AR) activity or, alternatively, may develop secondary resistance. Detection in patients’ circulating tumor cells (CTCs) of ARV7, a splicing variant of AR lacking the ligand-binding domain, showed a link with treatment failure. Independent confirmation of the predictive role of CTC status combined with ARV7 detection is, therefo...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Volume 47, Issue 1, December 2019, Page 2846-2854 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
Condition:   Cancer of the Prostate Intervention:   Other: no intervention (post study follow up) Sponsors:   Steba Biotech S.A.;   International Drug Development Institute;   ICON plc Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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