Iso- α-acids and matured hop bitter acids in beer improve obesity-induced cognitive impairment.
Iso-α-acids and matured hop bitter acids in beer improve obesity-induced cognitive impairment.
Biosci Biotechnol Biochem. 2019 Jun 14;:1-9
Authors: Ayabe T, Ohya R, Ano Y
Abstract
Dementia and cognitive decline have become public health issues worldwide and life-style-related diseases and obesity have recently been reported as key risk factors. We have recently demonstrated that short-term administration of iso-α-acids (IAAs), hop-derived bitter components of beer, improves spatial and object recognition memory. However, the short-term effects of IAAs on obesity-induced cognitive impairment remain to be investigated. Furthermore, although matured hop bitter acids (MHBAs) are also derived from hops, their effect on obesity-induced cognitive decline remains unknown. In the present study, the short-term administration of IAAs improved memory deficits in high-fat diet (HFD)-fed mice, as assessed in the novel object recognition test (NORT). Dietary MHBAs supplementation administered to HFD-fed mice prevented obesity and improved memory deficits in the NORT. Moreover, the short-term administration of MHBAs improved episodic and spatial reference memory in obese mice. These hop-derived bitter acids may contribute toward improving obesity-induced cognitive impairments. Abbreviations: IAAs: iso-α-acids; MHBAs: matured hop bitter acids; HFD: high fat diet; NORT: novel object recognition test; NOLT: novel object location test.
PMID: ...
Source: Bioscience, Biotechnology, and Biochemistry - Category: Biochemistry Authors: Ayabe T, Ohya R, Ano Y Tags: Biosci Biotechnol Biochem Source Type: research
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