Impact of mast cells in systemic lupus erythematosus: can inflammation be inhibited?

Impact of mast cells in systemic lupus erythematosus: can inflammation be inhibited? J Biol Regul Homeost Agents. 2019 May-Jun;33(3):669-673 Authors: Caraffa A, Gallenga CE, Kritas SK, Ronconi G, Conti P Abstract Systemic lupus erythematosus (SLE), is a complex chronic inflammatory autoimmune disease, with rheumatological manifestations, which afflicts mainly women. SLE presents various heterogeneous clinical aspects and different pathogeneses and involves the production of anti- DNA autoantibodies which are deposited as immune complexes in various organs and tissues, provoking inflammation. These diseases cause multiple tissue and organ damage in arthritis, skin lesions, hematologic changes, renal and neurologic disorders, and others (Table I). In SLE, serum contains anti-nucleus antibodies and anti-DNA antibodies that can be important biomarkers for patients suffering from this disease. PMID: 31195792 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research