Efficacy of Allogeneic Hematopoietic Cell Transplantation in Human T Cell Lymphotropic Virus Type 1 –Associated Adult T Cell Leukemia/Lymphoma: Results of a Systematic Review/Meta-Analysis

Adult T cell leukemia/lymphoma (ATLL) is a rare aggressive subtype of mature T cell neoplasms, described in 1977 in the first large case series by Uchiyama based on the unique clinical, cytologic, and epidemiologic characteristics of the disease [1]. The pathogenic role of human T cell lymphotropic virus type 1 (HTLV-1) in ATLL was later elucidated, corresponding with the endemic distribution of ATLL in Japan, Central Caribbean, tropical Africa, and South America [2 –4]. Four clinical subtypes have been proposed based on laboratory values and extent of clinical involvement: acute, lymphoma, chronic, and smoldering [5].

Source: Biology of Blood and Marrow Transplantation - May 23, 2019 Category: Hematology Authors: Madiha Iqbal, Tea Reljic, Farina Klocksieben, Taimur Sher, Ernesto Ayala, Hemant Murthy, Ali Bazarbachi, Ambuj Kumar, Mohamed A. Kharfan-Dabaja Source Type: research