Effects of Age Among Elderly Cancer Patients on Breakthrough Pain Management with Sublingual Fentanyl Tablets

AbstractIntroductionSublingual fentanyl tablets (SFTs) have been shown to be a safe and effective option in controlling breakthrough cancer pain (BTcP). However, further examination is required to investigate the use of SFTs among the elderly. The aim of this study was to examine the influence of age in BTcP management with SFTs in the elderly population.MethodsWe performed subgroup analyses of a recently completed trial in two subsets of individuals: patients aged 65 –74 years (low age group) and patients ≥ 75 years (high age group). Pain intensity (PI), onset of pain relief, frequency and duration of BTcP episodes, and adverse events (AEs) were assessed at 3, 7, 15, and 30 days. Health status instruments used were the Hospital Anxiety and Depression Scale (HADS-A and HADS-D) and the Short Form 12, version 2 (SF-12v2) questionnaire.ResultsLevels of PI at the end of the study improved significantly as compared with baseline in both the low and the high age groups (30.0% and 27.7% reduction, respectively). The onset of analgesia at the end of the study began in  
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research

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Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Autoimmune diseases Source Type: blogs
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
Karin Meissner1,2*, Nicola Talsky1, Elisabeth Olliges1,2, Carmen Jacob1,3,4, Oliver J. Stötzer5, Christoph Salat5, Michael Braun6 and Raluca Flondor1 1Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Munich, Germany 2Division of Health Promotion, Coburg University of Applied Sciences, Coburg, Germany 3Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom 4Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom 5Haematology and Oncology, Outpatient Cancer Ca...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
How Bad Is Fentanyl? Fentanyl is an extremely dangerous synthetic opioid. Unlike some other opioids that occur naturally, it is man-made for the purpose of helping aid people suffering from extreme pain. It can be administered for recovery after surgery, during cancer treatments or for recovery after a painful injury. The Drug Enforcement Administration (DEA) classifies fentanyl as a Schedule II controlled substance. This means that it is legal for medical use, however, it has an extremely high potential for abuse and addiction. Understanding Fentanyl Significantly stronger than morphine or oxycodone, Fentanyl can be fatal...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Drug Rehab Information Drug Treatment Heroin Painkiller Substance Abuse Synthetic fentanyl prescription drug abuse prescription drug addiction prescription drug detox prescription drug use p Source Type: blogs
This study investigated the influence of temperament on depression and anxiety in palliative care cancer patients. METHODS: A total of 53 patients at the palliative care unit (PCU) of the Medical University of Vienna were enrolled in the study. Patients filled out the TEMPS-M and the brief PHQ-9 questionnaires to examine associations between temperament, psychiatric symptoms and sociodemographic parameters. RESULTS: Pain (67%), anorexia (58%), constipation (42%) and nausea/vomiting (40%) were the most prevalent self-reported symptoms. Self-reported symptoms of depression were less commonly reported (21.8%) t...
Source: Wiener Klinische Wochenschrift - Category: General Medicine Authors: Tags: Wien Klin Wochenschr Source Type: research
Conclusion: Knowledge obtained from this study could be beneficial for better understanding, assessment, and management of symptom clusters in women with BC. It may also help patients to plan ahead for them to seek management of concurrent symptoms to improve their quality of life.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Tens of millions of Americans struggle to sleep at night, and many of them turn to sleeping pills for relief. Prescription and over-the-counter sleep aids are especially popular among older adults. A recent study published in the American Journal of Geriatric Psychiatry found that roughly one in three adults ages 65 to 80 use these drugs at least occasionally to fall asleep, and OTC meds like Benadryl and Tylenol PM are the pills of choice for sleepless seniors. Experts say this is concerning for a number of reasons. Studies have linked the regular, long-term use of OTC sleep medicines to some potentially serious side effe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Baby Boomer Health sleep Source Type: news
AbstractPurposeEarly integration of palliative care (PC) is recommended. The determination of predictors for patients ’ request for PC may guide implementation in clinical practice. Toward this end, we analyzed the symptom burden and distress of cancer patients in outpatient care and examined their need and request for PC.MethodsBetween October 2013 and March 2016, 705 patients receiving outpatient cancer treatment took part in the survey. We used the new MInimal DOcumentation System to detect symptom clusters. Additionally, patients ’ request for palliative and psychosocial support was assessed. Groups of pati...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
The story began a year ago, as did my divorce, but I will try my best to explain my relationship with Blake Chadick, as it was a major impact on me this past year, waiting for my divorce to be finalized.  I realize my blog is reading backwards at the moment, but should only be several entries or so.First of all, he's married.  He said his wife Melissa was very sick from the radiation treatment she received when she had colon (among other) cancers in 2011.  She slept half of the day, was in the the bathroom for the other half, and had a medication the constipated her for about 2 hours a day so she could be ac...
Source: bipolar.and.me - Category: Psychiatry Tags: @drinkbodyarmor @mamacof3 anxiety betrayal blake chadick depression lies Source Type: blogs
Background: Pain, depression, anxiety, sleep disturbances, and constipation were reported in different symptom clusters at different stages of breast cancer. Managing symptom clusters rather than individual symptoms can improve performance status. Aim: The study examined the effect of pain symptom cluster (pain and constipation) on performance when mediated by the psychoneurological symptom cluster (depression, anxiety, and sleep disturbances) using age as a moderator. Design: A secondary analysis.
Source: Pain Management Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research
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