Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery

In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. Design and Methods: In this randomized clinical trial, 180 patients with opioid use disorder who underwent orthopedic surgery under general anesthesia were randomly allocated into 3 groups. Patients in groups A, B, and C received intravenous lidocaine, ketamine, or normal saline, respectively, during the operation. Then, postoperative pain scores, analgesic requirements, patient satisfaction, and patient sleepiness were recorded and compared among the 3 groups. Results: Numerical rating scales during the first hour postoperation were significantly lower in the lidocaine group than in the ketamine or control group (P 
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research