Liquidambar styraciflua L.: A new potential source for therapeutic uses

Publication date: Available online 6 June 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Graziele Francine Franco Mancarz, Laressa Carolina Laba, Elaine Cristina Pinto da Silva, Maria Rosa Machado Prado, Lauro Mera de Souza, Daiany de Souza, Tomoe Nakashima, Rosiane Guetter MelloAbstractLiquidambar styraciflua L., ALTINGIACEAE, popularly known as sweet gum or alligator tree, is an aromatic tree with a natural distribution in North America and acclimated in Brazil. In traditional medicine, L. styraciflua L is used for the treatment of stomach disorders, wounds, and coughs. The present study was designed to investigate the biological potential and chemical profile of extracts obtained from aerial parts of L. styraciflua L. The chemical profile was established using liquid chromatography-mass spectrometry analysis and the extracts were tested for total phenolics, flavonoids, and tannins using spectrophotometric assays. The anti-inflammatory activity of L. styraciflua L was tested using an inhibition of hyaluronidase enzyme assay, and cytotoxic activities were tested by the 3-(4,5-dimethylthiazol-2 yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. The synergy between the plant extracts with ciprofloxacin and tetracycline was studied by the checkerboard assay method against eight bacterial strains.The phytochemical investigation showed that the leaves and stem are rich in phenolics compounds (1419.34–1614.02 mg GAE/g, 875.21-1557.57 mg GAE/g, resp...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research