The vertebral 3 ′-deoxy-3′- 18 F-fluorothymidine uptake predicts the hematological toxicity after systemic chemotherapy in patients with lung cancer

ConclusionsThe low18F-FLT uptake in the lower vertebral body is a predictor of severe HT in patients with lung cancer who receive platinum-doublet chemotherapy.Trial registrationTrial registration: UMIN000027540Key Points• The vertebral18F-FLT uptake with PET is an independent predictor of the severe hematological toxicity during the first cycle of platinum-doublet chemotherapy.• The18F-FLT uptake in L4 vertebral body estimated hematological toxicities better than that in the upper vertebra (Th4, Th8, and Th12).• The evaluation of the amount and activity of hematopoietic cells in the bone marrow cavity using18F-FLT PET imaging could provide predictive data of severe hematological toxicities and help determine an appropriate drug combination or dose intensity in patients with advanced malignant diseases.
Source: European Radiology - Category: Radiology Source Type: research