Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells.

Conclusions: Collectively, these observations suggest that nutrient stress induces the protein expression of both MITF and TFEB in ARPE-19 cells. TFEB-regulated transcriptional program plays an important role in adaptive response of cells during both nutrient and lysosomal stress. PMID: 31160892 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31160892?dopt=Abstract

Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: Pan HY, Alamri AH, Valapala M Tags: Cell Mol Biol Lett Source Type: research