Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPAR γ/SGK1 signaling pathway.

Conclusions: Rosiglitazone ameliorated the lung injury and promoted ENaC-mediated AFC via a PPARγ/SGK1-dependent signaling pathway, alleviating pulmonary edema in a mouse model of ALI.
PMID: 31160894 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - June 6, 2019 Category: Biochemistry Authors: He J, Qi D, Tang XM, Deng W, Deng XY, Zhao Y, Wang DX Tags: Cell Mol Biol Lett Source Type: research