Down-regulation of STIP1 regulate apoptosis and invasion of glioma cells via TRAP1/AKT signaling pathway

Glioma is the most common primary malignant tumor in the brain; it has the characteristics of “three highs and one low” and is characterized by and its high incidence, high recurrence rate, high mortality rate, and low cure rate (1,2). Glioblastoma is the most common type of glioma. The median overall survival time for glioblastoma is approximately 14.6 months, and with standard treatmen t and diagnosis, the 5-year survival rate is less than 9.8% (3,4). It is therefore imperative to study the molecular mechanisms of glioma and identify new treatment strategies.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research