Evaluation of glioma tumor volume with 18F-fluciclovine positron emission tomography interpreted in combination with MRI, compared with MRI alone: Results from a prospective phase 3 blinded image evaluation

Conclusions: 18F-Fluciclovine PET + CE-T1W MRI shows good diagnostic performance, with consistent image interpretation demonstrated across 3 naïve readers. 18F-Fluciclovine PET + CE-T1W MRI accurately identified higher tumor volumes than CE-T1W MRI alone and showed greater specificity than FLAIR (or T2W) MRI. The addition of 18F-fluciclovine PET to MRI has potential clinical value in delineating which part of the additional volume of abnormality shown on FLAIR is not malignant, thus more accurately identifying the extent of glioma prior to surgery or radiotherapy.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Miller, M., Langen, K.-J., Prasad, V., Yakushev, I., Gerber, J., Bronzel, M., Meyer, T., Chau, A., Stevens, D., Chisholm, D., Kluge, A. Tags: Brain PET/MRI Source Type: research