Hepatic Hemangiosarcoma in a Cynomolgus Macaque (Macaca fascicularis).

Hepatic Hemangiosarcoma in a Cynomolgus Macaque (Macaca fascicularis). Comp Med. 2019 May 29;: Authors: Bright LA, Gardiner KL, Veeder CL, Brice AK Abstract An experimentally naïve, 9-y-old, intact male cynomolgus macaque was reported for bleeding from an unidentified site. Sedated physical examination indicated mild gingival separation from the lingual aspect of the upper right canine tooth as the source of the hemorrhage. Physical exam revealed a firm mass adhered to the left zygomatic arch, 2 subcutaneous nodules on the chest, and a large mass in the cranial abdomen. Radiographs revealed a large soft-tissue mass in the cranial abdomen and multifocal nodules in the caudal lung fields. On ultrasonography, the liver was grossly enlarged and contained a cavitated mass. Hematology and serum chemistry results demonstrated severe regenerative anemia with normal clotting timesand adequate platelet count. For humane reasons, euthanasia was elected. On gross examination, the liver was markedlyenlarged by an expansile mass primarily affecting the median lobe, with multiple, smaller nodules throughout the remaininglobes. Multifocal round, firm nodules were observed on the surface of all lung lobes and throughout the omentum. Histologicexamination of the hepatic, cutaneous, osseous, and pulmonary lesions demonstrated well-defined, endothelium-lined vascular channels arranged in cords with abundant hemorrhage; endothelial-cell immunomarkers co...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research