Phenomenon-based evaluation of relative biological effectiveness of ion beams by means of the multiscale approach

ConclusionsGood agreement with a large set of experimental data on clonogenic cell survival, inactivation cross section, and RBE emphasizes the predictive power of the MSA. In the high-LET regime, the fact that a given number of ions may produce more damage than needed for a given biological effect leads to a significant (up to 20%) variation in RBE. Consideration of this effect in the analysis of experimental data on irradiation with high-LET ions may lead to re-evaluation of RBE in this regime.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research