Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9

ConclusionTaken together, the present findings suggested that matrine induced apoptosis and autophagy through down-regulating circ-104075 and Bcl-9 expression via inhibition of PI3K/AKT and Wnt-β-catenin pathways in glioma cells. The present study provides a foundation for further preclinical and clinical evaluations of matrine as a glioma therapy.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research