Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France.

Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France. Haematologica. 2019 May 16;: Authors: Bernaudin F, Dalle JH, Bories D, Peffault de Latour R, Robin M, Bertrand Y, Pondarre C, Vannier JP, Neven B, Kuentz M, Maury S, Lutz P, Paillard C, Yakouben K, Thuret I, Galambrun C, Dhedin N, Jubert C, Rohrlich P, Bay JO, Suarez F, Raus N, Vernant JP, Gluckman E, Poirot C, Socié G, Société Française de Greffe de Moelle et de Thérapie Cellulaire Abstract Allogeneic stem cell transplantation remains the only curative treatment for sickle-cell anemia, but the place of myeloablative conditioning remains to be defined. The aim of the present study was to analyze long-term outcomes, including chimerism, sickle-cell anemia-related events and biological data (hemoglobin, reticulocytes, HbS%), and fertility, in a French series of 234 SCA-patients younger than 30 years who received (1988-2012) a matched-sibling-donor stem cell transplantation following standardized myeloablative conditioning (Busulfan, Cyclophosphamide and rabbit anti-thymocyte globulin). Since the first report of the series (1988-2004), 151 new consecutive patients with sickle-cell anemia were similarly transplanted. Considering death, non-engraftment or rejection (donor cells<5%) as events, the 5-year event-free survival was 9...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research