Dynamic-clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations.

CONCLUSION: We validated the dynamic-clamp for ICaL , novel in atrial cardiomyocytes, and showed that EADs of various types are generated by widening (particularly asymmetrically) window-ICaL , and abolished by narrowing it. Window-ICaL -narrowing is a potential therapeutic mechanism worth pursuing in the search for improved anti-AF drugs. This article is protected by copyright. All rights reserved. PMID: 31093979 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research