MCP-1 Promotes Detrimental Cardiac Physiology, Pulmonary Edema and Death in the cpk model of Polycystic Kidney Disease.

We report that KO of MCP-1 in these mice increased survival. Surprisingly, however, there was no significant difference in renal macrophage concentration, nor was there improvement in cystic disease or kidney function. Examination of cpk mice revealed cardiac hypertrophy, and measurement of ECG parameters revealed cardiac repolarization abnormalities compared to non-cystic mice. MCP-1 KO did not affect the number of cardiac macrophages nor did it alleviate the cardiac aberrancies. However, MCP-1 KO did prevent development of pulmonary edema, which occurred in cpk mice, and promoted a decreased resting heart rate and an increased heart rate variability. These data suggest that MCP-1 altered cardiac/pulmonary function in cpk mice and promoted death outside of its role as a macrophage chemoattractant. PMID: 31091126 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research