Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models.

CONCLUSIONS: Our findings provide evidence that recipient c-Kit lineage cells contribute to vascular remodeling in an allograft transplantation model, in which the SCF/c-Kit axis is responsible for cell migration and hexokinase1-dependent metabolic reprogramming for SMC differentiation.
PMID: 31079549 [PubMed - as supplied by publisher]

Source: Circulation Research - May 12, 2019 Category: Cardiology Authors: Ni Z, Deng J, Potter CM, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q, Hu Y, Zhou B, Xu Q, Zhang L Tags: Circ Res Source Type: research