DNA repair gene (XRCC3) polymorphisms and its association with ovarian carcinoma in Egyptian patients

ConclusionDNA repair gene XRCC3 polymorphism rs 861539 T allele and the rs 861539 T/rs 1799794 A haplotype may boost the susceptibility to ovarian carcinoma with no correlation with the tumor histological subtypes and stages. They may be salutary as a DNA-based diagnostic biomarker for identifying the high-risk Egyptian females susceptible to ovarian cancer. More studies are needed to clarify the underlying mechanisms that can contribute to ovarian cancer, assess the cancer prognosis, and help to determine adequate therapy regimen.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research