Enabling insights into the maturation of the renin–angiotensin–aldosterone system in children—Development of a low-volume LC–MS assay for the simultaneous determination of aldosterone, its precursor, and main metabolite

ConclusionA simultaneous bioanalytical LC-HRMS assay for the determination of the biomarker aldosterone, its precursor, and main metabolite, utilizing 50 µL serum, was successfully established. This assay facilitates insight into the maturing RAAS from neonates up to adolescents.
Source: Steroids - Category: Drugs & Pharmacology Source Type: research