In Vivo Quantification of Cerebral Translocator Protein Binding in Humans Using 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide SPECT
Conclusion: As demonstrated within a group of stroke and GBM patients, 123I-CLINDE SPECT can be used for quantitative assessment of TSPO expression in vivo. Because of the absence of a region devoid of TSPO, reference tissue models should be used with caution. The 2-tissue-compartment kinetic analysis of a 90-min dynamic scan with arterial blood sampling is recommended for the quantification of 123I-CLINDE binding with SPECT.
Source: Journal of Nuclear Medicine - Category: Radiology Authors: Feng, L., Svarer, C., Thomsen, G., de Nijs, R., Larsen, V. A., Jensen, P., Adamsen, D., Dyssegaard, A., Fischer, W., Meden, P., Krieger, D., Moller, K., Knudsen, G. M., Pinborg, L. H. Tags: Clinical Investigations Source Type: research
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