PMS2 germline mutation c.943C > T (p.Arg315*) ‐induced Lynch syndrome‐associated ovarian cancer

ConclusionCarryingPMS2 germline mutations (c.943C>T) confers an extremely high susceptibility of suffering from LS ‐associated cancers. Thus, close clinical monitoring and prophylactic surgery is highly recommended to help reduce the morbidity and mortality of LS‐associated cancers.

Source: Molecular Genetics & Genomic Medicine - May 4, 2019 Category: Genetics & Stem Cells Authors: Xiaoqing Guo, Weimin Wu, Hao Gao, Xiaofeng Li, Qizhi He, Yong Zhu, Na Liu Tags: ORIGINAL ARTICLE Source Type: research