Molecular evolution of CRH and CRHR subfamily before the evolutionary origin of vertebrate
Publication date: Available online 28 April 2019Source: PeptidesAuthor(s): Jason Sai Wun On, Aloysius Wilfred Raj Arokiaraj, Billy Kwok Chong ChowAbstractCorticotropin-releasing hormone (CRH) is well-cited for its important role in governing the stress responses via neuroendocrine system in vertebrates. After the identification of homologs of CRH receptor (CRHR) in both deuterostome and arthropod lineages, it was suggested that the ancestral homolog of CRH-CRHR molecular system is present in the bilaterian. However, homolog sequences from arthropods differ considerably from vertebrate CRH-like peptide sequences. Due to the significant difference between the biological system, as well as the gene regulatory network, of protostome and that of vertebrate, physiological studies on the protostomes may not provide important insight into the evolutionary history of vertebrate CRH system, while tunicate and amphioxus, two close relatives to vertebrate, which have diverged before two rounds of whole genome duplication (2WGDs) do. Given the identification of amphioxus CRH-like peptide by our group, this review aims to reexamine the current hypotheses on the evolution of CRH subfamily. It is generally accepted that paralogs of CRH and CRHR have been produced through 2WGDs, which occurred during the early vertebrate evolution. The identification of a single crh-like gene in amphioxi and tunicates by in silico search and the presence of two paralogons with a total of 5 crh-like genes in g...
At least 22 people have developed some type of respiratory illness after vaping or using e-cigarettes
HIGH blood pressure is a common condition in the UK. Making certain lifestyle tweaks can help to lower a soaring reading. According to a recent study, a popular juice may also do the trick.
Review of "Atlas of Artifacts in Clinical Neurophysiology," by William O. Tatum, IV Atlas of Artifacts in Clinical Neurophysiology by William O. Tatum , IV, Demos Medical Publishing, 2018 , 419 pages. ISBN: 9780826169341 . E-book ISBN: 978-0826169358 . List Price: $185.00; Amazon New: $154.02; Amazon Used: $144.00; Kindle: $129.36. Neurodiagn J. 2019 Aug 23;:1-2 Authors: Clark-Bash RJ PMID: 31441708 [PubMed - as supplied by publisher]
Authors: Moosavian SP, Arab A, Mehrabani S, Moradi S, Nasirian M Abstract Background: Several studies have investigated the effect of omega-3 fatty acids and vitamin E on oxidative stress and inflammation, but their findings are inconsistent. The aim of this meta-analysis is to elucidate the overall effects of co-supplementation with omega-3 fatty acids and vitamin E on oxidative stress and inflammation. Methods: We searched titles, abstracts, and keywords of relevant articles indexed in PubMed, ISI, Scopus, and Google Scholar databases up to December 2018 to identify eligible RCT studies. Random effects model was...
Conclusion: These results provide a potential mechanism involving AMPK activation/ROS inhibition signaling pathway in osteogenic differentiation of BMSCs enhanced by resveratrol. It suggests that development of therapy towards ROS is an effective way for osteoporosis treatment. PMID: 31438780 [PubMed - in process]