Major kinds of drug targets in Chagas disease or American Trypanosomiasis.

Major kinds of drug targets in Chagas disease or American Trypanosomiasis. Curr Drug Targets. 2019 Apr 23;: Authors: Duschak VG Abstract Chagas disease, a parasitic infection commonly named American Trypanosomiasis affects millions of people all over Latin America. Presently, the number of international infected people estimated by the World Health Organization (WHO) amounts to 7 to 8 million and more than 10.000 deaths are assumed to happen yearly. The disease is an emergent disease elsewhere than non-endemic countries of the word due to transmission of etiologic agent, Trypanosoma cruzi by people migration. The best promising targets for trypanocidal drugs may be classified in three main groups: Group I will include main molecular targets considered among specific enzymes involved in essential processes for parasite survival, in particular Cruzipain the major cysteine protease of T. cruzi. Group II will contemplate biological pathways and their key specific enzymes, such as Sterol biosynthesis pathway, among others, specific antioxidant defense mechanisms, and bioenergetics ones. Group III will consider, the atypical organelles /structures present in the parasite relevant clinical forms, while are absent or considerably different from those present in mammals and biological processes related with them. These can be considered potential targets to develop drugs with extra effectiveness and fewer secondary effects than the currently ...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research