Retinal alterations in a pre-clinical model of an autism spectrum disorder

ConclusionsThis study establishes that adolescent male mice of the VPA-induced ASD model have alterations in retinal function and protein expression compatible with those found in several brain areas of other autism models. These results support the view that synaptic disturbances with excitatory/inhibitory imbalance early in life are associated with ASD and point to the retina as a window to understand their subjacent mechanisms.
Source: Molecular Autism - Category: Molecular Biology Source Type: research