Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma

(Children's Hospital of Philadelphia) Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and demonstrated minimal toxicity to surrounding organs.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: 1 August 2019Source: Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1861, Issue 8Author(s): Caterina Merla, Micaela Liberti, Claudia Consales, Agnese Denzi, Francesca Apollonio, Carmela Marino, Barbara BenassiAbstractBackgroundMolecular mechanisms of interaction between cells and extremely low frequency magnetic fields (ELF-MFs) still represent a matter of scientific debate. In this paper, to identify the possible primary source of oxidative stress induced by ELF-MF in SH-SY5Y human neuroblastoma cells, we estimated the induced electric field and current density at the cell level.MethodsWe fol...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Contributors : Sofie Mohlin ; Karin Hansson ; Daniel Bexell ; Kristoffer von StedingkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensneuroblastoma cells derived from PDOX models were treated with the kinase inhibitor.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
We report the application of RNA-Seq analysis to determine the transcriptional responses to Mn dose, ranging from physiological to toxicological levels in human SH-SY5Y neuroblastoma cells. We find that Mn dose showed widespread effects in abundance of protein coding genes for metabolism of reactive oxygen species, energy sensing, glycolysis, protein homeostasis including the unfolded protein response and transcriptional regulation. Adaptive responses at physiological Mn concentration-10 μM Mn for 5 h, a concentration that did not result in cell death after 24 h increased abundance of differentially expressed genes (DEG...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 19 June 2019Source: Neuroscience LettersAuthor(s): San-Ping Xie, Fan Zhou, Juan Li, Shu-jie DuanAbstractLong non-coding RNAs (lncRNAs) have been reported to play important roles in Parkinson’s disease (PD) pathogenesis. It was indicated that lncRNA nuclear enriched abundant transcript 1 (NEAT1) is involved in PD. However, the underlying mechanism of NEAT1 is still not fully explored. Human neuroblastoma cell line SH-SY5Y was treated with 1-Methyl-4-phenylpyridinium (MPP+) to mimic PD model in vitro. qRT-PCR was employed to detect the expression of NEAT1, IL-1β, IL-6 and TNF-&al...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionsThese findings suggest that we successfully established sensitive and stable H2O2 induced L166P DJ ‐1‐ and C106S DJ‐1‐transfected SH‐SY5Y cell models of PD andCistanche extracts may thus be useful for treating PD.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research
CCR Grand Rounds Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value. Exp Mol Pathol. 2019 Jun 17;:104272 Authors: El-Shazly SS, Hassan NM, Abdellateif MS, El Taweel MA, Abd-Elwahab N, Ebeid EN Abstract BACKGROUND: The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS: Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and PHOX...
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
We present a case of an incidentally diagnosed pelvic NBL arising from the dome of the UB in a 7-month-old infant. The mass was treated with surgical excision only after being classified as a very low risk group according to the International Neuroblastoma Risk Group staging system. The patient was disease free after 5 years of follow-up. Although rare, we suggest that NBL should be considered in the differential diagnosis of UB masses in children and investigated accordingly. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |...
Source: European Journal of Pediatric Surgery Reports - Category: Surgery Authors: Tags: Case Report Source Type: research
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