Resting-State Functional Connectivity Networks Associated with Fatigue in Multiple Sclerosis with Early Age Onset

ConclusionsrsfMRI identified Alterations in two distinct connections (the connectivity between insula and posterior cingulate gyrus and between the right thalamus and right precentral gyrus) that differed between fatigued and non-fatigued patients, as well as correlated with cognitive fatigue severity. These findings suggest that disruption of sensorimotor, high-order motor, and non-motor executive function likely contributes to the neural mechanism of fatigue in MS. Knowledge of the neural mechanisms of underlying MS fatigue could inform more effective treatment strategies.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research