Benefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions

Publication date: June 2019Source: Trends in Food Science & Technology, Volume 88Author(s): Marius Emil Rusu, Ramona Simedrea, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase, Daniela-Saveta Popa, Isabel C.F.R. FerreiraAbstractBackgroundIn the quest for a healthier and longer life, nutrition plays a key role. Tree nuts have a complex, health-promoting phytochemical profile, including proteins, mono and polyunsaturated fatty acids, polyphenols, vitamins, minerals, and the consumption of this food group can postpone aging and inhibit many age-related diseases.Scope and approachIn this review we focus on the biologically active compounds from tree nuts and the mechanisms of actions their intake have on delaying aging and prevent diseases linked with aging.Key findings and conclusionsScientific findings recommend the inclusion of tree nuts into the diet of mature adults. The consumption of tree nuts can mitigate the pro-inflammatory effects of Western diets and diminish the inflammation by decreasing the levels of reactive oxygen/nitrogen species and inflammatory molecules. Tree nuts modulate the Nrf2/EpRE and NF-κB signaling pathways, present cytoprotection, stimulate antioxidant and detox enzyme systems, and reduce inflammatory conditions. Similarly to calorie restriction, tree nuts positively affect the same specific cell signaling pathways: down-regulate PI3K/Akt/mTOR and insulin/IGF-1, prevent mitochondrial dysfunctions, promote mitochondrial biogenesis and energy homeostasi...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research