Cancers, Vol. 11, Pages 429: A Pilot Clinical Study on the Prognostic Relevance of Plasmatic Exosomes Levels in Oral Squamous Cell Carcinoma Patients

Conclusions: Surgical treatment induced a dramatic reduction of the plasmatic levels of exosomes expressing CD63 as early as 1 week after resection. This first result suggests that the tumour mass is responsible of the high levels of circulating exosomes detected in cancer patients. At the same time point exosome expressing CAV-1 increased, possibly due to the inflammatory reaction immediately after surgery. Lastly, statistical analysis showed that lower levels of plasmatic exosomes both before and after surgery correlated with a better life expectancy of OSCC patients. Hopefully, this approach will prove useful in the clinical follow-up of cancer patients.

Source: Cancers - March 25, 2019 Category: Cancer & Oncology Authors: Samuel Rodr íguez Zorrilla Mario P érez-Sayans Stefano Fais Mariantonia Logozzi Mercedes Gallas Torreira Abel Garc ía García Tags: Article Source Type: research