Bile modulates secretion of incretins and insulin: a study on human extrahepatic cholestasis.

CONCLUSIONS: Our findings suggest that acute extrahepatic cholestasis determines a significant impairment in the entero-endocrine gut-pancreatic secretory function. The altered bile flow might determine a direct deleterious effect on beta cell function perhaps mediated by the impairment of incretin hormone function.
PMID: 30874733 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Mezza T, Moffa S, Ferraro PM, Quero G, Capece U, Carfì A, Cefalo CMA, Cinti F, Sorice GP, Impronta F, Mari A, Pontecorvi A, Alfieri S, Holst JJ, Giaccari A Tags: J Clin Endocrinol Metab Source Type: research