Brain interrupted: Early life traumatic brain injury and addiction vulnerability.

Brain interrupted: Early life traumatic brain injury and addiction vulnerability. Exp Neurol. 2019 Mar 09;: Authors: Cannella LA, McGary H, Ramirez SH Abstract Recent reports provide evidence for increased risk of substance use disorders (SUD) among patients with a history of early-life traumatic brain injury (TBI). Preclinical research utilizing animal models of TBI have identified injury-induced inflammation, blood-brain barrier permeability, and changes to synapses and neuronal networks within regions of the brain associated with the perception of reward. Importantly, these reward pathway networks are underdeveloped during childhood and adolescence, and early-life TBI pathology may interrupt ongoing maturation. As such, maladaptive changes induced by juvenile brain injury may underlie increased susceptibility to SUD. In this review, we describe the available clinical and preclinical evidence that identifies SUD as a persistent psychiatric consequence of pediatric neurotrauma by discussing (1) the incidence of early-life TBI, (2) how preclinical studies model TBI and SUD, (3) TBI-induced neuropathology and neuroinflammation in the corticostriatal regions of the brain, and (4) the link between childhood or adolescent TBI and addiction in adulthood. In summary, preclinical research utilizes an innovative combination of models of early-life TBI and SUD to recapitulate clinical features and to determine how TBI promotes a risk for the development of SUD. H...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

Related Links:

The conversations -- all with college students between 18 and 21 -- give anecdotal looks into how the nicotine-addicted are dealing with what officials have called a public health crisis.
Source: - Health - Category: Consumer Health News Source Type: news
Publication date: 14 September 2019Source: New Scientist, Volume 243, Issue 3247Author(s): Moya SarnerA diagnosis that used to be for substance abuse now controversially spans all sorts of behaviours. Moya Sarner digs into the science
Source: New Scientist - Category: Science Source Type: research
Let’s dive into this week’s Psychology Around the Net for some perspective on how we decide to trust the news we trust, new research on a hormone we secrete when we’re panicked, a survey that shows happy people don’t just ignore the social issues around them, and more. Substance Use in the Food Service Industry: The American Addiction Centers recently conducted a survey that sheds some light on substance use among workers in the food service industry, an industry that is often stereotyped for drug and alcohol use. Among some of the findings: 10% of workers report they work while under the influence...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Adhd food service Forgetfulness Happiness Hormones Inattention osteocalcin Pollyanna hypothesis sexism Social Issues Stress Substance Use women Source Type: blogs
Publication date: Available online 12 September 2019Source: EXPLOREAuthor(s): Arya. Nielsen, L.Susan. WielandAbstractCochrane is an international non-profit organization established in 1993 to produce and disseminate high quality and unbiased systematic reviews of evidence on health care interventions. At the forefront of systematic review methodology, Cochrane is generally accepted to be among the most carefully prepared and rigorous sources of systematic review evidence. There are numerous Cochrane reviews on nonpharmacologic interventions for pain and multiple Cochrane reviews evaluating acupuncture therapy in pain cond...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
Although alcohol affects people in different ways and some people can drink more than others, drinking too much may cause a person to feel drunk. Learn more about the effects of alcohol by stage here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alcohol / Addiction / Illegal Drugs Source Type: news
AbstractHookah or waterpipe smoking or use is an emerging trend in the US population, especially among the youth. The misperception of hookah being less harmful than cigarettes and the availability of different but “appealing” flavors are considered among the main reasons for this trend. Hookah users however are exposed to many of the same toxic compounds/by-products as cigarette users, but at dramatically higher levels, which might lead to more severe negative health effects. In fact, hookah users are at risks of infections, cancers, lung disease, and other medical conditions. Moreover, because of the overlapp...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
The original article unfortunately contained a mistake. In the online version of the paper, the entire Box 1 is missing, and the labels of the 2 tables are swapped. The original version has been corrected.
Source: Current Addiction Reports - Category: Addiction Source Type: research
While Suboxone can be a helpful tool for many, it is important to also understand its addictive nature. Because it is an opioid, wondering if you can form an addiction to Suboxone can be answered simply: Yes. Although the rates of addiction are much smaller than those of other opioids, it is still important to take their addictive properties seriously and get help if you start to notice the signs and symptoms of addiction to Suboxone. What is Suboxone? According to their own website, Suboxone is a prescription medicine that contains the active ingredients buprenorphine and naloxone. It is used to treat adults who are depe...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Substance Abuse addiction treatment addictionologist detox drug detox medical detox medicated-assisted detox prescription drug detox prescription medication suboxone Source Type: blogs
Behavioral Neuroscientist Judith Grisel discusses how binge drinking impacts your brain chemistry and the genetic inclination toward addiction.
Source: Health News: - Category: Consumer Health News Source Type: news
Methamphetamine is involved in an increasing number of treatment admissions for heroin, especially among adolescents, astudy inAddiction has found.“The phenomenon of increasing methamphetamine use among people using opioids is of great concern,” Christopher M. Jones, Pharm.D., Dr.P.H., M.P.H., of the Centers for Disease Control and Prevention and colleagues wrote. “Methamphetamine use carries its own risks, including a range of physical and mental health consequences such as psychosis and other mental disorders; cognitive and neurologic deficits; cardiovascular and renal dysfunction; transmission of HIV, ...
Source: Psychiatr News - Category: Psychiatry Tags: addiction adolescents Christopher M. Jones heroin methamphetamine polysubstance use treatment Treatment Episode Data Set young adults Source Type: research
More News: Addiction | Brain | Child Development | Neurology | Neuroscience | Pathology | Pediatrics | Psychiatry | Science | Study