PD1 and PDL1 molecules control suppressor activity of regulatory T cells in chronic Chagas cardiomyopathy patients.

CONCLUSION: Our data indicate that the expressions of different molecules that induce apoptosis are associated with suppressive mechanisms mediated by Treg cells and suggest a possible role for PD1 and PDL1 molecules in the morbidity of chronic Chagas disease.
PMID: 30853363 [PubMed - as supplied by publisher]

Source: Human Immunology - March 6, 2019 Category: Allergy & Immunology Authors: Damasio MPS, Rocha MOC, Sousa GR, Ferreira KS, Valente VAA, Araujo FF, Medeiros NI, Chaves AT, Dutra WO, Correa-Oliveira R, Gomes JAS Tags: Hum Immunol Source Type: research