Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils.

Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils. Recent Pat Drug Deliv Formul. 2019 Mar 04;: Authors: Archana C, Amaldoss MJN Abstract BACKGROUND: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination. OBJECTIVE: The prime objective of the study is to prepare a nano dispersion with good stability indicating zeta potential. The formulations were prepared by varying concentrations of jojoba oil and grape seed oil which forms the hybrid nanoparticles with drug. METHOD: The high-pressure hot-homogenization technique was used to prepare the nanoparticles. The prepared nanoparticles were subjected to characterization analysis such as Mean particle size, Z-average, and Zeta potential by using dynamic light scattering (DLS) and photon correlation spectroscopy (PCS). The best formulation was subjected to Transmission electron microscopy (TEM) technique for surface morphology and other characterization. The crystalline pattern of the drug alone, drug-loaded nanoparticles and nanoparticles without the drug were studied by XRD. The dr...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research