Sleep helps to repair damaged DNA in neurons, scientists find

Chromosomes ’ movement when the brain is resting allows cells to mend DNAErnest Hemingway prized sleep for good reason. Not one to dwell on rest and recuperation, the novelist saw snoozing as a form of damage limitation. “I love sleep,” he once said. “My life has the tendency to fall apart when I’m awake.”The author ’s observation may be truer than he imagined. Scientists have discovered that broken DNA builds up in brain cells in the daytime and repair work reverses the damage only during sleep.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Science Sleep Biology Source Type: news

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In this study, after 2 weeks of chronic sleep deprivation in rats, the condylar cartilage exhibited rough surfaces, with a disorganized arrangement and partial sloughing of collagen fibers, decreased proliferation of chondrocytes, increased osteoclast activity in the calcified cartilage layer, and increased ratios of MMP-3/TIMP-1 and RANKL/OPG expression. After 4 weeks of LIPUS intervention in rats, the condylar cartilage displayed prominent reductions in these pathological changes, including noticeable repair of the injured cartilage structure, increased chondrocyte proliferation, a reduced number of osteoclasts, and mark...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Journal of Perinatology, Published online: 18 July 2019; doi:10.1038/s41372-019-0433-7Sleep-disordered breathing: an under-recognized problem in infants with myelomeningocele defects regardless of timing of repair
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Cancienne JM, Brockmeier SF, Deasey MJ, Werner BC Abstract BACKGROUND: A few investigations exist which evaluate the influence of obstructive sleep apnea (OSA) on complications after arthroscopic rotator cuff repair. METHODS: A database was queried for patients undergoing rotator cuff repair with and without OSA and further subdivided into those with and without a billing code for a continuous positive airway pressure (CPAP) device. Thirty-day and 6-month adverse events were assessed. RESULTS: After regression analysis, patients with OSA had markedly increased emergency department visits and hospital admission (P
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract A novel potential role of sleep is neuronal DNA repair. Live imaging of chromosome dynamics in zebrafish neurons has uncovered how sleep can repair DNA breaks accumulated during wake to maintain genome integrity and likely slow down neuronal aging. PMID: 31211981 [PubMed - in process]
Source: Current Biology - Category: Biology Authors: Tags: Curr Biol Source Type: research
 There are a huge number of individuals with mental illnesses who have successful, fulfilling careers, despite the setbacks of their illnesses. In this episode, we’re joined by Erika Nielsen, a professional cellist, who shares the story of her diagnosis, the changes she had to make in her life, what it was like “coming out” as having bipolar disorder, and much more.   Subscribe to Our Show! And Remember to Review Us! About Our Guest Erika Nielsen is a Canadian cellist, writer, and artist based in Toronto. Erika has a multi-faceted career as a chamber musician, collaborative arti...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar General Professional The Psych Central Show Career Gabe Howard Musician Vincent M. Wales Source Type: blogs
HIGH BLOOD pressure is known as the ‘silent killer’ and feelings of tiredness could mean you are at risk of having the condition. Sleep is vital for good health and for your body to repair itself, and there is a symptom in sleeping patterns that could mean you are at risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions Resuming PPV use after transsphenoidal surgery did not result in intracranial complications. However, delay in resuming PPV resulted in four patients requiring oxygen at home. We propose a preliminary PPV device management algorithm based on the size of the intraoperative CSF leak to facilitate future studies. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
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