Network-pharmacology-based identi fication of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.

CONCLUSIONS: Overall, our findings proved that EEOD could inhibit breast cancer metastasis by attenuating the expression of Cav-1, highlighting the use of EEOD as an adjunctive therapy for metastatic breast cancer patients. This study also provides novel insights into network pharmacology and bioinformatics analysis as effective tools to illuminate the scientific basis of TCM.
PMID: 30784915 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 20, 2019 Category: Drugs & Pharmacology Authors: Yang B, Wang N, Wang S, Li X, Zheng Y, Li M, Song J, Zhang F, Mei W, Lin Y, Wang Z Tags: Biomed Pharmacother Source Type: research